When discussing about "when is it IC to run" (or "is delivering mail a reason to run"), here's a look at pnp rules:
http://www.d20srd.org/srd/movement.htm
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Table: Movement and Distance
One Round (Tactical)1 Speed
15 feet 20 feet 30 feet 40 feet
Walk 15 ft. 20 ft. 30 ft. 40 ft.
Hustle 30 ft. 40 ft. 60 ft. 80 ft.
Run (×3) 45 ft. 60 ft. 90 ft. 120 ft.
Run (×4) 60 ft. 80 ft. 120 ft. 160 ft.
One Minute (Local) Speed
15 feet 20 feet 30 feet 40 feet
Walk 150 ft. 200 ft. 300 ft. 400 ft.
Hustle 300 ft. 400 ft. 600 ft. 800 ft.
Run (×3) 450 ft. 600 ft. 900 ft. 1,200 ft.
Run (×4) 600 ft. 800 ft. 1,200 ft. 1,600 ft.
One Hour (Overland) Speed
15 feet 20 feet 30 feet 40 feet
Walk 1½ miles 2 miles 3 miles 4 miles
Hustle 3 miles 4 miles 6 miles 8 miles
Run — — — —
One Day (Overland) Speed
15 feet 20 feet 30 feet 40 feet
Walk 12 miles 16 miles 24 miles 32 miles
Hustle — — — —
Run — — — —
I presume the "walk" and "run" in nwn2 represent walk and hustle here ("run" in pnp means sprinting for minimum of 6 seconds in a straight line - which isn't available to nwn2 PCs)
Also note that the rules do not allow you to "run" (or sprint) outside of combat. Which is the topic.
Hustling outside of combat:
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[b]Hustle[/b]
A character can hustle for 1 hour without a problem. Hustling for a second hour in between sleep cycles deals 1 point of nonlethal damage, and each additional hour deals twice the damage taken during the previous hour of hustling. A character who takes any nonlethal damage from hustling becomes fatigued.
A fatigued character can’t run or charge and takes a penalty of -2 to Strength and Dexterity. Eliminating the nonlethal damage also eliminates the fatigue.
Yes, it's rather pathetic that the hero can only run for one hour. But do note that most of our heroes carry around 50kg of stuff with them.
More pertaining to the "can I run delivering mail" is that a hustle is not an allowed means of movement on the scale of days. Which is ICly how long a mail run should take.
Finally on nonlethal damage:
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Healing Nonlethal Damage
You heal nonlethal damage at the rate of 1 hit point per hour per character level.
(Presumably nonlethal damage needs the time at rest to heal, ie. not while hustling)
So counting a day by the hours, hustling and resting is a possible form of movement. But taken in the scale of a few days trip (beregrost to BG), you'd have to be very high level to manage it. 8 hours of hustling means 1+2+4+8+16+32+64=127hp of nonlethal damage per day. (More than 8 hours is forced march with more damage!) Which you'd have to heal during one night, say 10hours, which means you need to be level 13 to keep on hustling for days. Level 13 PCs don't ICly bother running for normal mail, or if they do, something is horribly wrong.
But bottom line, if someone wants to RP a running courier, RPing the downtime and carrying minimal gear, there really shouldn't be a reason for a witch hunt. Especially for a low level PC "training". But if a level 10 tank strips down and goes "training" delivering mail when there's nothing else to do, I think it's ridiculous and somebody needs to look into the mirror. (But the biggest issue there is that high levels should get next to zero xp from static quests in the first place. Statics are there to help the low levels get a leg up.)
And please let's not start with a caster with access to healing/restoration being able to run. Because they are according to the rules, but let's just bust those favored souls of shandaukul for doping (your god forsakes you for trivially squandering his favors for pennies). Because we don't want players deciding the PC classes based on static-running, do we?